Both directors and screenwriters, Antonio and Marco Manetti make their directorial debut in 1995 with the short film Consegna a Domicilio a segment from the film DeGenerazione. In 1997, they direct their first feature film, Torino Boys produced by Marco and Piergiorgio Bellocchio. In 2000, their film Zora la vampira is released, followed, among others, by Piano 17, Paura 3D and L’arrivo di Wang which was selected for the Controcampo Italiano competing section at the Venice Film Festival.
In 2013 Song ‘e Napule is released, followed, in 2017, by Ammore e Malavita which was presented in competition at the Venice Film Festival and won several awards, including the David di Donatello for Best Film. In 2021, the first film of the Diabolik trilogy is released; it is the cinematographic adaptation of the adventures of the character created by Angela and Luciana Giussani.
The Manetti bros. have also directed television series, including the cult series L’ispettore Coliandro.
They also work in web production, and they have directed more than a hundred music videos for some of the most famous Italian music artists.